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2021 Mercedes-Benz S-Class for sale

AutoDealersHub has 5 listings for used 2021 Mercedes-Benz S-Class from local dealers, all 2021 models. Asking prices run from $45,150 to $54,995 with a median of $49,995, across 3 listings that show a price. 2 more listings ask you to contact the dealer for a price.

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Updated Nov 7, 2026, 7:22 AM ET

AutoDealersHub lists a small selection of used 2021 Mercedes-Benz S-Class vehicles from a few local dealers, mostly in Virginia. The listings are sedans, with gasoline engines and AWD.

AI summary generated from current AutoDealersHub listings. Counts and prices change as dealers update inventory.

In stock
5
from local dealers
Price range
$45,150–$54,995
median $49,995
Model years
2021
Top trims
S 580, S 580 4MATIC, S 580 4MATIC Sedan 4D

5 cars

Prices are the dealers' advertised prices. Taxes, title, registration and any dealer fees may be extra.

Highlights

  • Listings are mostly sedans
  • Popular trims include S 580 and S 580 4MATIC
  • Gasoline is the main fuel type
  • AWD is the most common drivetrain

AI summary generated from current AutoDealersHub listings. Counts and prices change as dealers update inventory.

Prices

Asking prices of the used 2021 Mercedes-Benz S-Class listed on AutoDealersHub, as of Nov 7, 2026.

Median asking price
$49,995
Lowest asking price
$45,150
Listings with a price
3
As of
Nov 7, 2026

Dealers' advertised asking prices; flagged placeholder and implausible prices are left out. How these figures are made

Other Mercedes-Benz S-Class model years

Frequently asked questions

How many used 2021 Mercedes-Benz S-Class are for sale on AutoDealersHub?

There are 5 listings for used 2021 Mercedes-Benz S-Class right now, from local dealers. Listings refresh from each dealer's inventory feed about every hour.

How much do used 2021 Mercedes-Benz S-Class cost?

Asking prices run from $45,150 to $54,995 with a median of $49,995, across 3 listings that show a price. 2 more listings ask you to contact the dealer for a price. These are the asking prices of the used 2021 Mercedes-Benz S-Class listed on AutoDealersHub right now.

Which Mercedes-Benz S-Class trims are listed?

The most-listed trims right now are S 580 (3), S 580 4MATIC (1) and S 580 4MATIC Sedan 4D (1).

Where do these listings come from?

Every listing comes from a DealersCloud dealer's own website inventory and is refreshed about every hour. AutoDealersHub does not sell cars: choosing View at dealer takes you to the dealer's listing, where you confirm availability and buy directly from the dealer.

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